Cranberry has a unique combination of phytochemicals which are used for treatment of various systemic diseases including oral diseases like caries,periodontitis and oral cancer. Many in vitro studies have outlined the potential health benefits of cranberry but in vivo studies are still inconclusive. Cranberry inhibit acid production, attachment and biofilm formation by Streptococcus mutans thereby being an effective anticaries agent. It also inhibits host inflammatory response and adherance of periodontal pathogens on tooth surfaces. Proanthocyanidins in cranberries demonstrate significant cancer prevention. The review aims to well into the potential benefits of cranberry in improving oral health as well as a peep into the still unexplored facets of natural medicaments in oral disease prevention.